Developing a multiple glazing system to minimize transmission of direct insolation for particular latitudes

Too often, in the last 50 years, the energy-thrift lessons of vernacular architecture have been forgotten or ignored. In the Middle East, many recently-designed commercial buildings, with large areas of glazing, incur excessively high electricity-demands to provide energy for the required air-conditioning plant. One way of reducing the magnitude of this demand is through better window design. A new glazing system is proposed that utilizes the insertion of a clear glazing element within the cavity of a double glazed window. The main objective of this system is to achieve acceptable levels of daylight within a building by attempting to maintain the diffuse component of insolation while reducing the penetration of direct component by using the increased reflectivity of these materials with the angle of incidence of the direct beam component of solar irradiation. By using clear glazing materials the proposed system attempts to achieve acceptable performance without the need for elaborate and expensive coatings or substrates. Because solar geometry varies with latitude a varying performance of glazing systems is expected with current glazing systems. However, the suggested system utilizes an optimal angle for overall daylighting and thermal performance that relates to the particular solar geometry of interest, New software is also developed to assess the performance of the suggested system; this involved examining all the modes of heat transfer through the entire glazing system. Results then were assessed to calculate the optimal angle of the element that corresponds to the solar geometry of particular latitude. Such proposal takes a new perspective, once it is acknowledged that though different forms of advanced glazing systems currently are being used to inhibit the penetration of direct solar radiation, still the main disadvantages of such advanced glazing systems are that they are relatively expensive and would reduce the penetration of a considerable part of the daylight entering the space

Pupil Localisation and Eye Centre Estimation using Machine Learning and Computer Vision

Various methods have been used to estimate the pupil location within an image or a real-time video frame in many fields. However, these methods lack the performance specifically in low-resolution images and varying background conditions. We propose a coarse-to-fine pupil localisation method using a composite of machine learning and image processing algorithms. First, a pre-trained model is employed for the facial landmark identification to extract the desired eye-frames within the input image. We then use multi-stage convolution to find the optimal horizontal and vertical coordinates of the pupil within the identified eye-frames. For this purpose, we define an adaptive kernel to deal with the varying resolution and size of input images. Furthermore, a dynamic threshold is calculated for reliable identification of the best-matched candidate. We evaluated our method using various statistical and standard metrics along-with a standardized distance metric we introduce first time in this study. Proposed method outperforms previous works in terms of accuracy and reliability when benchmarked on multiple standard datasets. The work has diverse artificial intelligence and industrial applications including human computer interfaces, emotion recognition, psychological profiling, healthcare and automated deception detection

Effect of different curing conditions on the mechanical properties of UHPFC

(Received: Match 20, 2013; Accepted in Revised Form: June 22, 2013) Abstract: Ultra-High Performance Fiber Concrete (UHPFC) is a new class of concrete. Because of its distinguished mechanical properties, UHPFC is considered as an ideal alternative material for use in developing new structural solutions. This paper discusses on influence of different curing conditions on mechanical properties of UHPFC. An experimental program was performed to study the mechanical properties of UHPFC which were cured under six different curing conditions. Test results indicated that steam and boil curing methods showed a promising performance particularly at early age of curing compared to other type of curing

Developing a multiple glazing system to minimize transmission of direct insolation for particular latitudes

Too often, in the last 50 years, the energy-thrift lessons of vernacular architecture have been forgotten or ignored. In the Middle East, many recently-designed commercial buildings, with large areas of glazing, incur excessively high electricity-demands to provide energy for the required air-conditioning plant. One way of reducing the magnitude of this demand is through better window design. A new glazing system is proposed that utilizes the insertion of a clear glazing element within the cavity of a double glazed window. The main objective of this system is to achieve acceptable levels of daylight within a building by attempting to maintain the diffuse component of insolation while reducing the penetration of direct component by using the increased reflectivity of these materials with the angle of incidence of the direct beam component of solar irradiation. By using clear glazing materials the proposed system attempts to achieve acceptable performance without the need for elaborate and expensive coatings or substrates. Because solar geometry varies with latitude a varying performance of glazing systems is expected with current glazing systems. However, the suggested system utilizes an optimal angle for overall daylighting and thermal performance that relates to the particular solar geometry of interest, New software is also developed to assess the performance of the suggested system; this involved examining all the modes of heat transfer through the entire glazing system. Results then were assessed to calculate the optimal angle of the element that corresponds to the solar geometry of particular latitude. Such proposal takes a new perspective, once it is acknowledged that though different forms of advanced glazing systems currently are being used to inhibit the penetration of direct solar radiation, still the main disadvantages of such advanced glazing systems are that they are relatively expensive and would reduce the penetration of a considerable part of the daylight entering the space.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Optimal Control of Molecular Motion Expressed Through Quantum Fluid Dynamics

A quantum fluid dynamic control formulation is presented for optimally manipulating atomic and molecular systems. In quantum fluid dynamic the control quantum system is expressed in terms of the probability density and the quantum current. This choice of variables is motivated by the generally expected slowly varying spatial-temporal dependence of the fluid dynamical variables. The quantum fluid dynamic approach is illustrated for manipulation of the ground electronic state dynamics of HCl induced by an external electric field.Comment: 18 pages, latex, 3 figure

Human leukocyte antigen supertype matching after myeloablative hematopoietic cell transplantation with 7/8 matched unrelated donor allografts: a report from the Center for International Blood and Marrow Transplant Research

The diversity of the human leukocyte antigen (HLA) class I and II alleles can be simplified by consolidating them into fewer supertypes based on functional or predicted structural similarities in epitope-binding grooves of HLA molecules. We studied the impact of matched and mismatched HLA-A (265 versus 429), -B (230 versus 92), -C (365 versus 349), and -DRB1 (153 versus 51) supertypes on clinical outcomes of 1934 patients with acute leukemias or myelodysplasia/myeloproliferative disorders. All patients were reported to the Center for International Blood and Marrow Transplant Research following single-allele mismatched unrelated donor myeloablative conditioning hematopoietic cell transplantation. Single mismatched alleles were categorized into six HLA-A (A01, A01A03, A01A24, A02, A03, A24), six HLA-B (B07, B08, B27, B44, B58, B62), two HLA-C (C1, C2), and five HLA-DRB1 (DR1, DR3, DR4, DR5, DR9) supertypes. Supertype B mismatch was associated with increased risk of grade II-IV acute graft-versus-host disease (hazard ratio =1.78, P=0.0025) compared to supertype B match. Supertype B07-B44 mismatch was associated with a higher incidence of both grade II-IV (hazard ratio=3.11, P=0.002) and III-IV (hazard ratio=3.15, P=0.01) acute graft-versus-host disease. No significant associations were detected between supertype-matched versus -mismatched groups at other HLA loci. These data suggest that avoiding HLA-B supertype mismatches can mitigate the risk of grade II-IV acute graft-versus-host disease in 7/8-mismatched unrelated donor hematopoietic cell transplantation when multiple HLA-B supertype-matched donors are available. Future studies are needed to define the mechanisms by which supertype mismatching affects outcomes after alternative donor hematopoietic cell transplantation

Internet-based search of randomised trials relevant to mental health originating in the Arab world

BACKGROUND: The internet is becoming a widely used source of accessing medical research through various on-line databases. This instant access to information is of benefit to busy clinicians and service users around the world. The population of the Arab World is comparable to that of the United States, yet it is widely believed to have a greatly contrasting output of randomised controlled trials related to mental health. This study was designed to investigate the existence of such research in the Arab World and also to investigate the availability of this research on-line. METHODS: Survey of findings from three internet-based potential sources of randomised trials originating from the Arab world and relevant to mental health care. RESULTS: A manual search of an Arabic online current contents service identified 3 studies, MEDLINE, EMBASE, and PsycINFO searches identified only 1 study, and a manual search of a specifically indexed, study-based mental health database, PsiTri, revealed 27 trials. CONCLUSION: There genuinely seem to be few trials from the Arab world and accessing these on-line was problematic. Replication of some studies that guide psychiatric/psychological practice in the Arab world would seem prudent

Endogenous tumor suppressor microRNA-193b: Therapeutic and prognostic value in acute myeloid leukemia

Purpose Dysregulated microRNAs are implicated in the pathogenesis and aggressiveness of acute myeloid leukemia (AML). We describe the effect of the hematopoietic stem-cell self-renewal regulating miR-193b on progression and prognosis of AML. Methods We profiled miR-193b-5p/3p expression in cytogenetically and clinically characterized de novo pediatric AML (n = 161) via quantitative real-time polymerase chain reaction and validated our findings in an independent cohort of 187 adult patients. We investigated the tumor suppressive function of miR-193b in human AML blasts, patient-derived xenografts, and miR-193b knockout mice in vitro and in vivo. Results miR-193b exerted important, endogenous, tumor-suppressive functions on the hematopoietic system. miR-193b-3p was downregulated in several cytogenetically defined subgroups of pediatric and adult AML, and low expression served as an independent indicator for poor prognosis in pediatric AML (risk ratio 6 standard error, 20.56 6 0.23; P = .016). miR-193b-3p expression improved the prognostic value of the European LeukemiaNet risk-group stratification or a 17-gene leukemic stemness score. In knockout mice, loss of miR-193b cooperated with Hoxa9/Meis1 during leukemogenesis, whereas restoring miR-193b expression impaired leukemic engraftment. Similarly, expression of miR-193b in AML blasts from patients diminished leukemic growth in vitro and in mouse xenografts. Mechanistically, miR-193b induced apoptosis and a G1/S-phase block in various human AML subgroups by targeting multiple factors of the KIT-RAS-RAF-MEK-ERK (MAPK) signaling cascade and the downstream cell cycle regulator CCND1. Conclusion The tumor-suppressive function is independent of patient age or genetics; therefore, restoring miR-193b would assure high antileukemic efficacy by blocking the entire MAPK signaling cascade while preventing the emergence of resistance mechanisms

Large Asymmetric Hypertrophy of Rectus Abdominis Muscle in Professional Tennis Players

Purpose: To determine the volume and degree of asymmetry of the musculus rectus abdominis (RA) in professional tennis players. Methods: The volume of the RA was determined using magnetic resonance imaging (MRI) in 8 professional male tennis players and 6 non-active male control subjects. Results: Tennis players had 58 % greater RA volume than controls (P = 0.01), due to hypertrophy of both the dominant (34% greater volume, P = 0.02) and non-dominant (82 % greater volume, P = 0.01) sides, after accounting for age, the length of the RA muscle and body mass index (BMI) as covariates. In tennis players, there was a marked asymmetry in the development of the RA, which volume was 35 % greater in the non-dominant compared to the dominant side (P,0.001). In contrast, no sideto-side difference in RA volume was observed in the controls (P = 0.75). The degree of side-to-side asymmetry increased linearly from the first lumbar disc to the pubic symphysis (r = 0.97, P,0.001). Conclusions: Professional tennis is associated with marked hypertrophy of the musculus rectus abdominis, which achieves a volume that is 58 % greater than in non-active controls. Rectus abdominis hypertrophy is more marked in the non-dominant than in the dominant side, particularly in the more distal regions. Our study supports the concept that humans can differentially recruit both rectus abdominis but also the upper and lower regions of each muscle. It remains to b

Polymorphisms in Toll-like receptor genes influence antibody responses to cytomegalovirus glycoprotein B vaccine

<p>Abstract</p> <p>Background</p> <p>Congenital Cytomegalovirus (CMV) infection is an important medical problem that has yet no current solution. A clinical trial of CMV glycoprotein B (gB) vaccine in young women showed promising efficacy. Improved understanding of the basis for prevention of CMV infection is essential for developing improved vaccines.</p> <p>Results</p> <p>We genotyped 142 women previously vaccinated with three doses of CMV gB for single nucleotide polymorphisms (SNPs) in TLR 1-4, 6, 7, 9, and 10, and their associated intracellular signaling genes. SNPs in the platelet-derived growth factor receptor (PDGFRA) and integrins were also selected based on their role in binding gB. Specific SNPs in TLR7 and IKBKE (inhibitor of nuclear factor kappa-B kinase subunit epsilon) were associated with antibody responses to gB vaccine. Homozygous carriers of the minor allele at four SNPs in TLR7 showed higher vaccination-induced antibody responses to gB compared to heterozygotes or homozygotes for the common allele. SNP rs1953090 in IKBKE was associated with changes in antibody level from second to third dose of vaccine; homozygotes for the minor allele exhibited lower antibody responses while homozygotes for the major allele showed increased responses over time.</p> <p>Conclusions</p> <p>These data contribute to our understanding of the immunogenetic mechanisms underlying variations in the immune response to CMV vaccine.</p